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2007-2008
Biological Chemistry Distinguished Lecture Series
Dr. Rebecca Heald, PhD
Department of Molecular & Cell Biology
University of California, Berkeley
Berkeley, CA, USA
"Mechanisms
of Mitotic Spindle Assembly and Function"
Seminar: Monday, May 5, 2008
12:00 1:00pm
NPI Auditorium - C8-183
CHS
poster
Research Description
Dr.
Heald's lab research focuses on mechanisms that organize
and segregate daughter chromosomes during
mitosis. To ensure high fidelity in these processes, metazoans
have evolved a macromolecular machine - the spindle - that
forms temporarily during mitotic stages. Utilizing primarily
Xenopus, her lab has been able to identify several distinct
pathways that contribute to the formation and maintenance
of the mitotic spindle. These experiments succeeded by
combining the power of spindle formation in vitro with
elegant biochemical and high-resolution imaging techniques.
Her work has revolutionized classic models of spindle formation & function
by including the diversity of biology acting during mitosis.
Distinguished Lecture Series Journal Club
Thursday, May 1, 2008
2:30-4:30pm
BSRB 383
Hosted by:
Brian Head (x61755, bhead@mednet.ucla.edu) and Arpi Siyahian
(x52880, asiyahian@mednet.ucla.edu)
Suggested Reading:
1) Analysis of a RanGTP-regulated gradient in mitotic somatic
cells.
Petr Kalab, Arnd Pralle, Ehud Y. Isacoff, Rebecca Heald & Karsten
Weis. Nature 440: 697-701 (March 30, 2006).
2) Xenopus
tropicalis egg extracts provide insight into scaling of
the mitotic
spindle. Katherine S. Brown, Michael D. Blower, Thomas
J. Maresca, Timothy
C. Grammer, Richard M. Harland, and Rebecca Heald. JCB 176(6):
765-770 (March 12, 2007).
3) Review: Mechanisms of mitotic spindle assembly and function.
Claire E. Walczak & Rebecca Heald. International Review of Cytology 265:
111-158 (2008).
updated:
May 1, 2008
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