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Weekly Schedule

Week 2

Week 7

Week 3

Week 8

 


Course Organization and Times:

Description: . . . . . .See . . . .Course Description

Professors:

Tim Lane (Biological Chemistry) Luisa Iruela Arispe (MCDB)

Office: 13-262 Factor

Office: 559A MBI

email: tlane@mednet.ucla.edu

email: arispe@mbi.ucla.edu

Location and Times

Tuesdays 2-4pm

Boyer Hall 130 (MBI, First floor Library.)

Credits and requirements

2 units

1st year Access graduate student standing, sign up with the Access Student Affairs Officer [SueEllen Parsee]

Maximum enrollment: 18

Grading Basis

Students will be graded on:

Attendance
Demonstrated knowledge, as shown though consistent participation.
Delivery of a 40 minute Powerpoint (ppt) Presentation covering an assigned paper [Notes on: PowerPoint ].
A short written assignment, to be handed in at the beginning of each class

DOWNLOAD the Weekly Assignment here ->: HTML version, PDF version

The presenter will provide the instructor with a formated disk containing one copy of their ppt presentation and should print out copies of their ppt presentations for the class (3 slides/page x 30 copies).

 

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[ACCESS to PDF Files Will Be Provided to Registered Students Only] A temporary problem may exist if several students are downloading papers at the same time. If you run into a problem, Try again later.

Topics and Papers

DISCLAIMER: The documents on this website are copyright protected and are only for use by participants in MBI297. Please use the individual Journals www sites to access articles for all other applications.

Suggested Reviews

REVIEW 1.

Manning 2002. The Protein Kinase Complement of the Human Genome.  Science  298:1912-

REVIEW 2

Blume-Jensen 2001. Oncogenic kinase signalling. Nature 411: 355-365.

REVIEW 3

Hubbard 2000. Protein Tyrosine Kinase Structure and Function. Annu. Rev. Biochem. 69:373-398.

REVIEW 4.

Huse 2002.  The Conformational Plasticity of Protein Kinases.  Cell. 109, 275-282.

REVIEW 5.

Kurosaki 2002. Regulation of B-cell signal transduction by adaptor proteins. Nature Reviews 2:354-363.

REVIEW 6.

Billadeau 2002.  ITAMs versus ITIMs: striking a balance during cell regulation. J. Clin. Invest. 109:161-168.

REVIEW 7.

Tonks 2001.  Combinatorial control of the specificity of protein tyrosine Phosphatases. Current Opinion in Cell Biology. 13:182195

REVIEW 8.

Parsons 2000. Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement. Oncogene 19. 5606-5613.

REVIEW 9.

Jiang 1999. Receptor signaling: When dimerization is not enough. Current Biology 1999. 9:R568R571.

REVIEW 10.

Hubbard 2002. Protein tyrosine kinases: autoregulation and small-molecule Inhibition. Current Opinion in Structural Biology. 12:735741.

REVIEW 11.

Schlessinger 2000. Cell Signaling by Receptor Tyrosine Kinases. Cell 103: 211-225.

REVIEW 12.

Morin 2000. From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents. Oncogene 19: 6574-6583

REVIEW 13.

Shannon 2002. Resistance in the land of molecular cancer therapeutics. Cancer Cell 2: 99-102.

 

Week 1 (1/7/03): TOPIC ASSIGNMENT / INTRO BY INSTRUCTORS

Papers: None required, but try to read a couple of the reviews.....

Week 2 (1/14/03):

Paper 1 NAME: JENNIFER WOO

Robinson et al. 2000 The protein tyrosine kinase family of the human genome, Oncogene 19: 5548-555

Paper 2 NAME: LUCIA GRAHAM

Kim et al. 2002.Receptor-Dependent and Tyrosine Phosphatase-Mediated Inhibition of GSK3 Regulates Cell Fate Choice. Developmental Cell. 3: 523-532.

Paper 3 NAME: AMY HENKENIUS

Kloth et al. 2002. STAT5b, a Mediator of Synergism between c-Src and the EGF Receptor. JBC Papers in Press. Published on November 11, 2002 as Manuscript M207289200

Week 3 (1/21/03):

Paper 1 NAME: FRANCISCO MALDONADO

Okumura et al. 2002. Akt inhibits Myt1 in the signaling pathway that leads to meiotic G2/M-phase transition. Nature Cell Biology, 4: 11-116

Paper 2 NAME: KATHERINE BREECE

Hanson et al. 2002. Regulation of the dephosphorylation of Stat6: Participation of Y713 in the IL4R a, the tyrosine phosphatase SHP1, and the proteasome. JBC Papers in Press. Published on November 28, 2002 as Manuscript M211747200

Paper 3 NAME: CHAD BARBER

Shishinn Sun and Bettie M. Steinberg 2002. PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. Journal of General Virology, 83: 1651-1658.

Week 4 (1/28/03):

Paper 1 NAME: ROBERT STEWART

Moro et al. 2002. Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines. The Journal of Biological Chemistry 277 (11): 9405-9414.

 

Paper 2 NAME: SYLVIA LOPEZ

Tzeng-Horng Leu, and Ming-Chei Maa. 2002 Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397. Oncogene 21: 6992-7000.

Week 5 (2/4/03):

Paper 1 NAME: MOVSES KARAKOSSIAN

Wakabayashi et al. 2002. A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor. Science 298: 2392- 2395

Paper 2 NAME: PHILLIP HUANG

Sancho et al. 2002. TCR Engagement Induces Proline-Rich Tyrosine Kinase-2 (Pyk2) Translocation to the T Cell-APC Interface Independently of Pyk2 Activity and in an Immunoreceptor Tyrosine-Based Activation Motif-Mediated Fashion. The Journal of Immunology. 292-300.

Paper 3 NAME: SWAPAN MEHTA

Newman et al. 2002. Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck. Blood. 97(8) 2351- 2357.

Week 6 (2/11/03):

Paper 1 NAME: EDGAR SUQUILANDA

Gerber et al. 2002. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. 417: 954- 958

Paper 2 NAME: NATALIA MATTAN

Takahashi et al. 2001.A single auto phosphorylation site on KDR/Flk-1 is essential for VEGF-A- dependent activation of PLC-g and DNA synthesis in vascular endothelial cells. EMBO journal 20(11) 2768-2778

Paper 3 NAME: YEN-TUNG LIOU

Hiratsuka et al.1998. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Developmental Biology 95:9349—9354,

Week 7 (2/18/03):

Paper 1 NAME: JACQUELIN SERVIN

Cong et al. 2002. Interaction between UV-damaged DNA Binding Activity Proteins and the c-Abl Tyrosine Kinase. The Journal of Biological Chemistry, 277(38) :34870-34878.

Paper 2 NAME: MASKIT MAYMON

Shah et al.2002. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2: 117-125

Paper 3 NAME: JAY BARRY

Tognon et al.2002. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2 : 367- 376

Week 8 (2/25/03):

Paper 1 NAME: CHENGYI JENNY SHU

Chan et al. 2002. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell. 1 : 181-191

Paper 2 NAME: DEVON LAWSON

Kan et al. 2002. Genomic Screening of Fibroblast Growth-Factor Receptor 2 Reveals a Wide Spectrum of Mutations in Patients with Syndromic Craniosynostosis. Am. J. Hum. Genet. 70:472-486.

Paper 3 NAME: FULAI JIN

Tartaglia et al. 2001. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nature Genetics 29:465-468

Week 9 (3/4/03):

Paper 1 NAME: JUNE ROUND

Cao et al. 2002. A Phosphotyrosine-dependent Protein Interaction Screen Reveals a Role for Phosphorylation of Caveolin-1 on Tyrosine 14. The Journal of Biological Chemistry, 277:8771-8774

Paper 2 NAME: RICHARD LLEWELLYN

Shah et al. 2002. A Chemical Genetic Screen for Direct v-Src Substrates Reveals Ordered Assembly of a Retrograde Signaling Pathway. Chemistry & Biology, 9: 35-47

Paper 3 NAME: TAMAR TOMASSIAN

Chan et al. 2002. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell. 2: 257-267

*DISCLAIMER: The documents on this website are copyright protected and are only for use by participants in MBI297. Please use the individual Journals www sites to access articles for all other applications.

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Students and Registration:

Registration.....UCLA Access Program OFFICE

STUDENTS (Alphabetical)
email
BARBER, CHAD
cbarber@ucla.edu
BARRY, JAY
jay_a_barry@hotmail.com
BREECE, KATHERINE
kbreecea@ucla.edu
GRAHAM, LUCIA
lgrahams@ucla.edu
HENKENIUS, AMY
amyhenkenius@hotmail.com
HUANG, PHILLIP
phuang1@sbcglobal.net
JIN, FULAI
fulaijin@hotmail.com
KARAKOSSIAN, MOVSES
movsesk@ucla.edu
LAWSON, DEVON
devonal13@ucla.edu
LIOU YEN-TUNG
ytliou@ucla.edu
LLEWELLYN, RICHARD
llewelr@yahoo.com
LOPEZ, SYLVIA
mistressyl@yahoo.com
MALDONADO, FRANCISCO
fjmaldonado999@yahoo.com
MATTAN, NATALIA
nsmattan@yahoo.com
MAYMON MASKIT
maskit@ucla.edu
MEHTA, SWAPAN
sticks19@hotmail.com
ROUND, JUNE
juneround@yahoo.com
SERVIN, JACQUELIN
curemenow@aol.com
SHU, CHENGYI JENNY
mashiara1@yahoo.com
 
STEWART, ROBERT
stewartr@ucla.edu
SUQUILANDA, EDGAR
esuqui@hotmail.com
TOMASSIAN, TAMAR
tamart@ucla.edu
WOO, JENNIFER
jwooyin@ucla.edu

 

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Site Manager & Links
Send comments and suggestions to tlane@mednet.ucla.edu

 

 

 

 

 

 

 

MBI 297 "TYROSINE KINASES

IN PHYSIOLOGY AND DISEASE"

UCLA, Access/MBI Graduate Course

Offered: winter Quarter 2002-03