Welcome to the Guo Lab



Structure and Function of Non-coding RNAs

The functions of RNA extend far beyond coding for amino acid sequences. The Guo research group is interested in elucidating how non-coding RNAs function by forming defined three-dimensional structures and by interacting with proteins. In particular, we are investigating how a class of small RNAs (called microRNA or miRNA) is processed and used as guides for target recognition in RNA interference. These projects will be investigated using X-ray crystallography, biochemistry and in vitro evolution methods.