Guo Lab: Publications


Quick-Cleveland J., Jacob J.P., Weitz S.H., Shoffner G., Senturia R., and Guo F. (2014) The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep. 7(6):1994-2005. Link

Weitz S.H., Gong M., Barr I., Weiss S., and Guo F. (2014) Processing of microRNA primary transcripts requires heme in mammalian cells. Proc. Natl. Acad. Sci. USA. 111(5):1861-6. Link

Senturia, R., Laganowsky, A., Barr, I., Brooke D. Scheidemantle, B.D., and Guo, F. (2012) Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. PLoS ONE 7(7): e39688. Link

Gong, M., Chen, Y., Senturia, R., Ulgherait, M., Faller, M., and Guo, F. (2012) Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8. Protein Sci. 21: 797-808. Link

Barr I., Smith A.T., Chen Y., Senturia R., Burstyn J., Guo F. (2012) Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc. Natl. Acad. Sci. USA. 109(6):1919-1924. Link

Barr I., Smith A.T., Senturia R., Chen Y., Scheidemantle B.D., Burstyn J., Guo F. (2011) DiGeorge Critical Region 8 (DGCR8) is a double-cysteine-ligated heme protein. J. Biol. Chem. 286(18):16716-25. Link

Faller, M., Toso, D., Matsunaga, M., Atanasov, I., Senturia, R., Chen, Y., Zhou, Z.H., and Guo, F. DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA. 2010; 16: 1570-1583. Link

Senturia, R., Faller, M., Yin, S., Loo, J.A., Cascio, D., Sawaya, M.R., Hwang, D., Clubb, R.T., and Guo, F. Structure of the dimerization domain of DiGeorge Critical Region 8. Protein Sci. 2010; 19: 1354-1365. Link

Miallau Linda, Faller Michael, Chiang Janet, Arbing Mark, Guo Feng, Cascio Duilio, Eisenberg David Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 2009; 284(1): 276-83. Link

Wang Qi, Barr Ian, Guo Feng, Lee Christopher Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene. RNA. 2008; 14(12): 2478-88. Link

Faller Michael, Guo Feng MicroRNA biogenesis: there's more than one way to skin a cat. Biochimica et biophysica acta. 2008; 1779(11): 663-7. Link

Faller, M., Matsunaga, M., Yin, S., Loo, J., and Guo, F. Heme is involved in microRNA processing. Nature Structural & Molecular Biology. 2007; 14(1): 23-29. Link

Guo, F., Gooding, A.R. and Cech, T.R. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006; 12: 387-395. Link

Guo, F Gooding, AR Cech, TR Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Molecular cell. 2004; 16(3): 351-62. Link

Guo, F Cech, TR Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nature structural biology. 2002; 9(11): 855-61. Link

Guo, F Cech, TR In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron. RNA. 2002; 8(5): 647-58. Link

Guo, F Gopaul, DN Van Duyne, GD Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse. Proceedings of the National Academy of Sciences of the United States of America. 1999; 96(13): 7143-8. Link

Gopaul, DN Guo, F Van Duyne, GD Structure of the Holliday junction intermediate in Cre-loxP site-specific recombination. The EMBO journal. 1998; 17(14): 4175-87. Link

Guo, F Gopaul, DN van Duyne, GD Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Nature. 1997; 389(6646): 40-6. Link