2013

Pecot MY, Tadros W, Nern A, Bader M, Chen Y, Zipursky SL. Multiple interactions control synaptic layer specificity in the Drosophila visual system. Neuron. 2013 Jan 23;77(2):299-310.link Link to PubMed

2012

Wu W, Ahlsen G, Baker D, Shapiro L, Zipursky SL. Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo. Neuron. 2012 Apr 26;74(2):261-8.link Link to PubMed

2011

Pappu KS, Morey M, Nern A, Spitzweck B, Dickson BJ, Zipursky SL.Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7571-6.link Link to PubMed

2010

Zipursky SL, Sanes JR. Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly. Cell. 2010 Oct 29;143(3):343-53.link

Millard SS, Lu Z, Zipursky SL, Meinertzhagen IA. Drosophila Dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Neuron. 2010 Sep 9;67(5):761-8.link

Pappu KS, Zipursky SL. Axon guidance: repulsion and attraction in roundabout ways. Curr Biol. 2010 May 11;20(9):R400-2. link

Sanes JR, Zipursky SL. Design principles of insect and vertebrate visual systems. Neuron. 2010 Apr 15;66(1):15-36. link

2009

Hattori D, Chen Y, Matthews BJ, Salwinski L, Sabatti C, Grueber WB, Zipursky SL. Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. Nature. 2009 Oct 1;461(7264):644-8. link

Zhu Y, Nern A, Zipursky SL, Frye MA. Peripheral visual circuits functionally segregate motion and phototaxis behaviors in the fly. Curr Biol. 2009 Apr 14;19(7):613-9. link

2008

Morey M, Yee SK, Herman T, Nern A, Blanco E, Zipursky SL. Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons. Nature. 2008 Dec 11;456(7223):795-9. link

Hattori D, Millard SS, Wojtowicz WM, Zipursky SL. Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol. 2008;24:597-620. link

Bharucha KN, Tarr P, Zipursky SL. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. J Exp Biol. 2008 Oct;211(Pt 19):3103-10. link

Sawaya MR, Wojtowicz WM, Andre I, Qian B, Wu W, Baker D, Eisenberg D, Zipursky SL. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell. 2008 Sep 19;134(6):1007-18. link

Millard SS, Zipursky SL. Dscam-mediated repulsion controls tiling and self-avoidance. Curr Opin Neurobiol. 2008 Feb;18(1):84-9. Epub 2008 Jun 4. Review. link

Black DL, Zipursky SL. To cross or not to cross: alternatively spliced forms of the Robo3 receptor regulate discrete steps in axonal midline crossing. Neuron. 2008 May 8;58(3):297-8. Review. link

Nern A, Zhu Y, Zipursky SL. Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron. 2008 Apr 10;58(1):34-41. link

Cayirlioglu P, Kadow IG, Zhan X, Okamura K, Suh GS, Gunning D, Lai EC, Zipursky SL. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science. 2008 Feb 29;319(5867):1256-60. link

2007

Ting CY, Herman T, Yonekura S, Gao S, Wang J, Serpe M, O'Connor MB, Zipursky
SL, Lee CH. Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron. 2007 Dec 6;56(5):793-806.

Wojtowicz WM, Wu W, Andre I, Qian B, Baker D, Zipursky SL. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell. 2007 Sep 21;130(6):1134-45.

Hattori D, Demir E, Kim HW, Viragh E, Zipursky SL, Dickson BJ. Dscam diversity is essential for neuronal wiring and self-recognition. Nature. 2007 Sep 13;449(7159):223-7.

Millard SS, Flanagan JJ, Pappu KS, Wu W, Zipursky SL. Dscam2 mediates axonal tiling in the Drosophila visual system. Nature. 2007 Jun 7;447(7145):720-4.

Matthews BJ, Kim ME, Flanagan JJ, Hattori D, Clemens JC, Zipursky SL, Grueber WB. Dendrite self-avoidance is controlled by Dscam. Cell. 2007 May 4;129(3):593-604.

2006

Zipursky SL, Wojtowicz WM, Hattori D. Got diversity? Wiring the fly brain with Dscam. Trends Biochem Sci. 2006 Oct;31(10):581-8. Epub 2006 Aug 21. Review.

Zhu H, Hummel T, Clemens JC, Berdnik D, Zipursky SL, Luo L. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat Neurosci. 2006 Mar;9(3):349-55. Epub 2006 Feb 12.

2005

Nern A, Nguyen LV, Herman T, Prakash S, Clandinin TR, Zipursky SL. An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12944-9. Epub 2005 Aug 25.

Sang TK, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, Jackson GR. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 2005 Feb 1;14(3):357-72. Epub 2004 Dec 8.

2004

Graveley BR, Kaur A, Gunning D, Zipursky SL, Rowen L, Clemens JC. The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA. 2004 Oct;10(10):1499-506.

Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004 Sep 3;118(5):619-33.

Zhan XL, Clemens JC, Neves G, Hattori D, Flanagan JJ, Hummel T, Vasconcelos ML, Chess A, Zipursky SL. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron. 2004 Sep 2;43(5):673-86.

Hummel T, Zipursky SL. Afferent induction of olfactory glomeruli requires N-cadherin. Neuron. 2004 Apr 8;42(1):77-88.

2003

Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet. 2003 Oct 15;12(20):2669-78. Epub 2003 Aug 27.

Lee RC, Clandinin TR, Lee CH, Chen PL, Meinertzhagen IA, Zipursky SL. The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci. 2003 Jun;6(6):557-63.

Hummel T, Vasconcelos ML, Clemens JC, Fishilevich Y, Vosshall LB, Zipursky SL. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron. 2003 Jan 23;37(2):221-31.

2002

Clandinin TR, Zipursky SL. Making connections in the fly visual system. Neuron. 2002 Aug 29;35(5):827-41. Review.

Tsuda L, Nagaraj R, Zipursky SL, Banerjee U. An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling. Cell. 2002 Sep 6;110(5):625-37.

Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science. 2002 Oct 18;298(5593):608-11. Epub 2002 Aug 15.

Hummel T, Attix S, Gunning D, Zipursky SL. Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron. 2002 Jan 17;33(2):193-203.

Suh GS, Poeck B, Chouard T, Oron E, Segal D, Chamovitz DA, Zipursky SL. Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron. 2002 Jan 3;33(1):35-46.

2001

Clandinin TR, Lee CH, Herman T, Lee RC, Yang AY, Ovasapyan S, Zipursky SL. Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron. 2001 Oct 25;32(2):237-48.

Schmucker D, Zipursky SL. Signaling downstream of Eph receptors and ephrin ligands. Cell. 2001 Jun 15;105(6):701-4. Review.

Lee CH, Herman T, Clandinin TR, Lee R, Zipursky SL. N-cadherin regulates target specificity in the Drosophila visual system. Neuron. 2001 May;30(2):437-50.

Poeck B, Fischer S, Gunning D, Zipursky SL, Salecker I. Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila. Neuron. 2001 Jan;29(1):99-113.

2000

Clandinin TR, Zipursky SL. Afferent growth cone interactions control synaptic specificity in the Drosophila visual system. Neuron. 2000 Nov;28(2):427-36.

Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 9;101(6):671-84.

Rao Y, Pang P, Ruan W, Gunning D, Zipursky SL. brakeless is required for photoreceptor growth-cone targeting in Drosophila. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5966-71.

1999

Hing H, Xiao J, Harden N, Lim L, Zipursky SL. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell. 1999 Jun 25;97(7):853-63.

Garrity PA, Lee CH, Salecker I, Robertson HC, Desai CJ, Zinn K, Zipursky SL. Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron. 1999 Apr;22(4):707-17.

Dong X, Tsuda L, Zavitz KH, Lin M, Li S, Carthew RW, Zipursky SL. ebi regulates epidermal growth factor receptor signaling pathways in Drosophila. Genes Dev. 1999 Apr 15;13(8):954-65.

Desai CJ, Garrity PA, Keshishian H, Zipursky SL, Zinn K. The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron. Development. 1999 Apr;126(7):1527-35.

1998

Salecker I, Clandinin TR, Zipursky SL. Hedgehog and Spitz: making a match between photoreceptor axons and their targets. Cell. 1998 Nov 25;95(5):587-90. Review.

Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 1998 Sep;21(3):633-42.

Tessier-Lavigne M, Zipursky SL. Development. Editorial overview. Curr Opin Neurobiol. 1998 Feb;8(1):13-7. Review.

Rao Y, Zipursky SL. Domain requirements for the Dock adapter protein in growth- cone signaling. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2077-82.

1997

Pignoni F, Hu B, Zavitz KH, Xiao J, Garrity PA, Zipursky SL. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell. 1997 Dec 26;91(7):881-91. Erratum in: Cell 1998 Feb 20;92(4):following 585.

Zavitz KH, Zipursky SL. Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression. Curr Opin Cell Biol. 1997 Dec;9(6):773-81. Review.

Pignoni F, Hu B, Zipursky SL. Identification of genes required for Drosophila eye development using a phenotypic enhancer-trap. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9220-5.

Thomas BJ, Zavitz KH, Dong X, Lane ME, Weigmann K, Finley RL Jr, Brent R, Lehner CF, Zipursky SL. roughex down-regulates G2 cyclins in G1. Genes Dev. 1997 May 15;11(10):1289-98.

Pignoni F, Zipursky SL. Induction of Drosophila eye development by decapentaplegic. Development. 1997 Jan;124(2):271-8.

Dong X, Zavitz KH, Thomas BJ, Lin M, Campbell S, Zipursky SL. Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Genes Dev. 1997 Jan 1;11(1):94-105.

1996

Dokucu ME, Zipursky SL, Cagan RL. Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina.
Development. 1996 Dec;122(12):4139-47.

Garrity PA, Rao Y, Salecker I, McGlade J, Pawson T, Zipursky SL. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell. 1996 May 31;85(5):639-50.

Finley RL Jr, Thomas BJ, Zipursky SL, Brent R. Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3011-5.

1995

Garrity PA, Zipursky SL. Neuronal target recognition. Cell. 1995 Oct 20;83(2):177-85. Review.

Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P. Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705.

Martin KA, Poeck B, Roth H, Ebens AJ, Ballard LC, Zipursky SL. Mutations disrupting neuronal connectivity in the Drosophila visual system. Neuron. 1995 Feb;14(2):229-40.

1994

Thomas BJ, Zipursky SL. Early pattern formation in the developing Drosophila eye. Trends Cell Biol. 1994 Nov;4(11):389-94.

Cheyette BN, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron. 1994 May;12(5):977-96.

Biggs WH 3rd, Zavitz KH, Dickson B, van der Straten A, Brunner D, Hafen E, Zipursky SL. The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J. 1994 Apr 1;13(7):1628-35.

Brunner D, Oellers N, Szabad J, Biggs WH 3rd, Zipursky SL, Hafen E. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell. 1994 Mar 11;76(5):875-88.

Zipursky SL, Rubin GM. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu Rev Neurosci. 1994;17:373-97. Review.

1993

Ebens AJ, Garren H, Cheyette BN, Zipursky SL. The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. Cell. 1993 Jul 16;74(1):15-27.

Hart AC, Harrison SD, Van Vactor DL Jr, Rubin GM, Zipursky SL. The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5047-51.

Hart AC, Krämer H, Zipursky SL. Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature. 1993 Feb 25;361(6414):732-6.

Biggs WH 3rd, Zipursky SL. Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6295-9. Erratum in: Proc Natl Acad Sci U S A 1993 Jul 1;90(13):6377.

1992

Cagan RL, Krämer H, Hart AC, Zipursky SL. The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand. Cell. 1992 May 1;69(3):393-9.

Zipursky SL, Krämer H, Cagan R, Hart A, Vactor DV Jr. Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. Cold Spring Harb Symp Quant Biol. 1992;57:381-9.

1991

Van Vactor DL Jr, Cagan RL, Krämer H, Zipursky SL. Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell. 1991 Dec 20;67(6):1145-55.

Krantz DD, Zidovetzki R, Kagan BL, Zipursky SL. Amphipathic beta structure of a leucine-rich repeat peptide. J Biol Chem. 1991 Sep 5;266(25):16801-7.

Krämer H, Cagan RL, Zipursky SL. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. Nature. 1991 Jul 18;352(6332):207-12.

1990

Hart AC, Krämer H, Van Vactor DL Jr, Paidhungat M, Zipursky SL. Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev. 1990 Nov;4(11):1835-47.

Krantz DE, Zipursky SL. Drosophila chaoptin, a member of the leucine-rich repeat family, is a photoreceptor cell-specific adhesion molecule. EMBO J. 1990 Jun;9(6):1969-77.

Banerjee U, Zipursky SL. The role of cell-cell interaction in the development of the Drosophila visual system. Neuron. 1990 Feb;4(2):177-87. Review.

1989

Zipursky SL. Molecular and genetic analysis of Drosophila eye development: sevenless, bride of sevenless and rough. Trends Neurosci. 1989 May;12(5):183-9. Review.

1988

Reinke R, Zipursky SL. Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development. Cell. 1988 Oct 21;55(2):321-30.

Reinke R, Krantz DE, Yen D, Zipursky SL. Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human. Cell. 1988 Jan 29;52(2):291-301.

Van Vactor D Jr, Krantz DE, Reinke R, Zipursky SL. Analysis of mutants in chaoptin, a photoreceptor cell-specific glycoprotein in Drosophila, reveals its role in cellular morphogenesis. Cell. 1988 Jan 29;52(2):281-90.

1985

Zipursky SL, Venkatesh TR, Benzer S. From monoclonal antibody to gene for a neuron-specific glycoprotein in Drosophila. Proc Natl Acad Sci U S A. 1985 Mar;82(6):1855-9.

1984

Zipursky SL, Venkatesh TR, Teplow DB, Benzer S. Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes. Cell. 1984 Jan;36(1):15-26.

1983

Reinberg D, Zipursky SL, Weisbeek P, Brown D, Hurwitz J. Studies on the phi X174 gene A protein-mediated termination of leading strand DNA synthesis. J Biol Chem. 1983 Jan 10;258(1):529-37.

Brown DR, Reinberg D, Schmidt-Glenewinkel T, Zipursky SL, Hurwitz J. Analysis of the phiX174 gene A protein using in vitro DNA replication systems. Methods Enzymol. 1983;100:217-39.

Brown DR, Reinberg D, Schmidt-Glenewinkel T, Roth M, Zipursky SL, Hurwitz J. DNA structures required for phi X174 A-protein-directed initiation and termination of DNA replication. Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:701-15.

1982

Fujita SC, Zipursky SL, Benzer S, Ferrús A, Shotwell SL. Monoclonal antibodies against the Drosophila nervous system. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7929-33.

Marians KJ, Soeller W, Zipursky SL. Maximal limits of the Escherichia coli replication factor Y effector site sequences in pBR322 DNA.
J Biol Chem. 1982 May 25;257(10):5656-62.

1981

Reinberg D, Zipursky SL, Hurwitz J. Separate requirements for leading and lagging strand DNA synthesis during phi X A protein-dependent RF goes to RF DNA replication in vitro. J Biol Chem. 1981 Dec 25;256(24):13143-51.

Zipursky SL, Marians KJ. Escherichia coli factor Y sites of plasmid pBR322 can function as origins of DNA replication. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6111-5.

Heidekamp F, Baas PD, van Boom JH, Veeneman GH, Zipursky SL, Jansz HS. Construction and characterization of recombinant plasmid DNAs containing sequences of the origin of bacteriophage phi X174 DNA replication. Nucleic Acids Res. 1981 Jul 24;9(14):3335-54.

1980

Zipursky SL, Marians KJ. Identification of two Escherichia coli factor Y effector sites near the origins of replication of the plasmids (ColE1 and pBR322. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6521-5.

Zipursky SL, Reinberg D, Hurwitz J. In vitro DNA replication of recombinant plasmid DNAs containing the origin of progeny replicative form DNA synthesis of phage phi X174. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5182-6.