Congratulations Dr. Weizhe Hong!

Congratulations Dr. Weizhe Hong!

Congratulations to Dr. Weizhe Hong for receiving a David and Lucile Packard Fellowship in Science and Engineering. This fellowship is given to early-career scientists who are taking big risks to perform creative and pioneering research in all areas of science and engineering. Dr. Hong's research aims to understand the genetic basis of social behavior.
https://www.packard.org/what-we-fund/science/packard-fellowships-for-science-and-engineering/fellowship-directory/weizhe-hong/

The Christofk lab publishes a paper titled "Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization" in Cell.

The Christofk lab publishes a paper titled "Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization" in Cell.

By William J. Sullivan, Peter J. Mullen, Ernst W. Schmid, Thomas Q. de Aguiar Vallim, William E. Lowry, Heather R. Christofk 

The metabolic state of a cell is influenced by cellextrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis of glycolytic drivers identified the hyaluronan-mediated motility receptor as being among the most highly correlated with glycolysis in cancer. Confirming a mechanistic link between the ECM component hyaluronan and metabolism, treatment of cells and xenografts with hyaluronidase triggers a robust increase in glycolysis. This is largely achieved through rapid receptor tyrosine kinasemediated induction of the mRNA decay factor ZFP36, which targets TXNIP transcripts for degradation. Because TXNIP promotes internalization of the glucose transporter GLUT1, its acute decline enriches GLUT1 at the plasma membrane. Functionally, induction of glycolysis by hyaluronidase is required for concomitant acceleration of cell migration. This interconnection between ECM remodeling and metabolism is exhibited in dynamic tissue states, including tumorigenesis and embryogenesis.

The complete article can be found here.

Tenure-Track Faculty Position

Tenure-Track Faculty Position 

Share This Post:

Assistant Researcher Position

Assistant Researcher Position

Desscription: 
Oversee operation of BRI Microscopic Techniques and Electron Microscopy Core Facilities. Provide teaching and supervision in the areas of histological technology, immunohistochemistry, electron microscopy, research methods, experimental design-related problem solving, laboratory equipment, and other areas within the purview of the Core Facility, to scientific investigators, postdocs, students, and other Core Facility users. Major duties include teaching, supervision, technical support, laboratory management, project management, space utilization, and consultation on issues related to research projects and methodology. Perform laboratory tasks and maintain a professional environment for the facility. Train and supervise students and less trained staff in proper protocols and safety procedures required in the Core. Keep records of procedures and training performed. Establish and implement laboratory safety practices as required by EH&S.
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy
Please be advised that the final candidate recommended for hire into a critical (or otherwise designated) position will be required to successfully complete a background investigation. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
UCLA is a Tobacco-Free environment. For more information, please view the policy at Tobacco-Free Campus Policy

https://recruit.apo.ucla.edu/apply/JPF03967

Phone: (310) 825-2834  
https://zipursky.dgsom.ucla.edu/pages/
LSchreiber@mednet.ucla.edu

 

Mitochondria Symposium

UCLA is hosting a one day Mitochondria Symposium.

UCLA is hosting a one day Symposium with the goal of discussing exciting ongoing research involving many aspects of mitochondrial study, such as bioenergetics, dynamics and genetics. Come and listen to 7 top mitochondrial scientists. Take the opportunity to interact and show them your research projects.

Enjoy a networking lunch with the speakers and display your mitochondrial work during the Junior Research Talks Competition and the Poster Session. You have the opportunity to win one of our 6 prizes

More information at https://www.uclamitosymposium.com/ or contact us at uclamitomeeting@gmail.com

 

UCLA Department of Biological Chemistry/ UCLA-DOE Institute Genomics and Proteomics

JOB POSTING: Assistant Researcher

Researcher Series
UCLA Department of Biological Chemistry/ UCLA-DOE Institute 

The Department of Biological Chemistry/ UCLA-DOE Institute for Genomics and Proteomics (http://www.biolchem.ucla.edu/), a basic science department within the UCLA David Geffen School of Medicine, invites highly qualified applications for positions as Assistant Researcher.

Brief Job Description:

Highly qualified, highly experienced applicants are invited to apply for a position of Assistant Researcher to develop a synthetic biochemistry platform for the production of biofuels and commodity chemicals. The Assistant Researcher will lead a team to build extremely stable enzymes for synthetic biochemistry systems. The ideal applicant will have extensive experience in protein structural biology, protein engineering, protein design, and structure determination. Extensive experience with molecular biology techniques is required. Proven independent creative research, mentoring and teamwork abilities are highly desired.

The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy.

Visiting https://recruit.apo.ucla.edu/apply/JPF02999 for a complete description of the position, required and desired qualifications, and application instructions. Job post will close on June 10, 2017.

 

Congratulations Weizhe Hong!

Dr. Weizhe Hong has been selected to the 2017 class of the Searle Scholars! Congratulations Weizhe!!
http://newsroom.ucla.edu/dept/faculty/ucla-neuroscientist-is-named-a-2017-searle-scholar

Congratulations Weizhe Hong!

Congratulations to Dr. Weizhe Hong for being selected as a 2017 Alfred P. Sloan Research Fellow in Neuroscience! The fellowships are “awarded yearly to 126 researchers in recognition of distinguished performance and a unique potential to make substantial contributions to their field.”
https://sloan.org/fellowships/2017-Fellows

Welcome Tom!

The Biological Chemistry Department welcomes our newest faculty member, Tom Vallim.

Assistant Professor, Biological Chemistry
Assistant Professon, Medicine/Cardiology

Dr. Vallim is an Assistant Professor in the Department of Biological Chemistry and in the Department of Medicine, Division of Cardiology at UCLA. Dr. Vallim was born in Brazil and emigrated to England as a teenager. In England, Dr. Vallim received his M.Sci and Ph.D from the University of Nottingham. As an undergraduate Ph.D student, Dr. Vallim’s research focused was on the transcriptional regulation of genes in lipid metabolism by dietary factors. In 2008, Dr. Vallim came to UCLA for his post-doctoral studies in the laboratory of Peter Edwards. At UCLA, Dr. Vallim’s research was focused on identifying molecular mechanisms that underlie the regulation of bile acid metabolism, the major pathway of cholesterol excretion from the body. In 2013, Dr. Vallim was promoted to Assistant Professor in the Division of Cardiology at UCLA, and in 2016, Dr. Vallim also joined the Department of Biological Chemistry. Dr. Vallim runs the lab jointly with his wife, Dr. Elizabeth Tarling, an Assistant Professor in the Division of Cardiology at UCLA. In 2013, Dr. Vallim was awarded the George J. Popják award from the UCLA Atherosclerosis Research Unit (ARU). In 2015, Dr. Vallim won the Irvine H. Page award by the American Heart Association and in 2016, the David L. Williams award at the Kern Lipid Conference. Dr. Vallim’s research is funded by the American Heart Association (AHA) and National Institute of Health (NIH). His research interests are in identifying molecular regulators of pathways that control lipid metabolism in health and disease.

http://www.biolchem.ucla.edu/people/faculty/thomas-vallim

 

UCLA Department of Biological Chemistry/ UCLA-DOE Institute

JOB POSTING: Assistant Researcher

Researcher Series
UCLA Department of Biological Chemistry/ UCLA-DOE Institute 

The Department of Biological Chemistry/ UCLA-DOE Institute (http://www.biolchem.ucla.edu/), a basic science department within the UCLA School of Medicine, invites highly qualified applications for positions as Assistant Researcher. Qualified candidates with a Ph.D. in biology, biochemistry, molecular, cell biology, or related fields, are encouraged to apply.

Job Duties:

  1. Standard molecular biology techniques including construction and preparation of recombinant bacterial plasmids for expression of proteins in bacteria.

  2. Synthesis of peptides, carrying natural and non-natural amino acids.

  3. Affinity purification, HPLC and mass spectrometry analysis of peptides and protein.

  4. Protein aggregation assays, such as Thioflavin T or Congo Red assays.

  5. Electron microscopy of amyloid fibrils and samples of interest.

  6. Protein gel electrophoresis under denaturing and non-denaturing conditions.

  7. Western-blot and dot-blot techniques for the detection of amyloid proteins.

  8. Preparation of cell lines and primary neuronal cultures.

  9. Cell-based toxicity assays, including analysis of the cell cycle phase, the level of reactive oxygen species, apoptosis,

    viability, metabolic activity etc.

  10. Structural analysis of peptides and proteins, by x-ray crystallography, circular dichroism (CD) and nuclear magnetic

    resonance (NMR), among other techniques.

  11. Design and perform in vivo experiments to study amyloid diseases.

  12. Analysis of data generated from in vivo experiments.

  13. Take appropriate actions to optimize and troubleshoot individual techniques as well as overall experiments. Recognize

    and take appropriate action when extended or repeated tests are required to produce meaningful results.

The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy. UC Nondiscrimination & Affirmative Action Policy

Visit https://recruit.apo.ucla.edu/apply/JPF02768 for a complete description of the position, required and desired qualifications, and application instructions. Job post will close January 22, 2017. 

Pages

Subscribe to  Department of Biological Chemistry, UCLA RSS