"Unlocking the Vault"

An article published by Drs. Leonard Rome and Kathleen Kelly in International Innovation. Click here to read the full version.

Grant will advance UCLA research on lung cancer treatment

National Cancer Institute gives $1 million for research on vault nanomedicine treatment for lung cancer

The treatment combines an immunotherapy agent called CCL21 with a drug delivery nanotechnology using biological particles called vaults. It was developed by Dr. Leonard Rome, associate director of UCLA’s California NanoSystems Institute, and Dr. Steven Dubinett, director of the UCLA Clinical Translational Science Institute, both of whom are also members of UCLA’s Jonsson Comprehensive Cancer Center.

Click here to read the full article in UCLA newsroom


Jen Quick-Cleveland receives Audree Fowler Fellowship

Congratulations to graduate student Jen Quick-Cleveland for receiving the Audree Fowler Fellowship in Protein Science!

Jen Quick-Cleveland, a graduate student from Dr. Feng Guo's lab will receive up to $5,000 to be used for scientific travel, books, supplies, computers, and software. The graduate student fellowship was made possible by a very generous gift from Dr. Audree Fowler from UCLA.  Click here to learn more abut the fellowship and to see the list of past recipients.


Assistant Professor Position

The Department is seeking candidates for a tenure-track faculty position.

The Department of Biological Chemistry (http://www.biolchem.ucla.edu), a basic science department within the UCLA School of Medicine, is seeking applicants with a PhD and/or MD degree for a tenure-track faculty position in any area of biochemistry, molecular, cell, or developmental biology. Although preference will be given to applicants at the Assistant Professor level, exceptional candidates at the Associate or Professor level are also encouraged to apply. Applicants should have an excellent record of creative research accomplishments. The new faculty member will be expected to develop an innovative research program addressing fundamental biological questions and to contribute to departmental teaching. The position is state-supported with a guaranteed salary base, outstanding fringe benefits, and substantial start-up funds.

Candidate selection will begin December 1, 2014, and will continue until the position is filled. Applicants should submit a full curriculum vitae, a description of research plan (3-page limit excluding references), and three letters of reference electronically at https://recruit.apo.ucla.edu under the “Biological Chemistry” heading (posting # JPF00463). References may submit their letters directly through the same website.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination & Affirmative Action Policy

Banerjee selected as the 117th Faculty Research Lecturer

Utpal Banerjee is chosen to speak in UCLA's most distinguished lecture series.

Dr. Uptal Banerjee will speak on the topic of "Oncogenes, Metabolism, Development, Cancer and the Little Fruit Fly That Could." on Monday, October 6 at 3pm in Schoenberg Hall, UCLA Schoenberg Music Building. Reception will immediately follow. See attached flyer.

The biannual Faculty Research Lecture series at UCLA presents the work of the university’s most distinguished scholars. Its purpose is to recognize their superb achievements, and give the campus and the greater community an opportunity to gain a new perspective on scholarly achievements and the viewpoints of the faculty honored. View webcasts of past lectures. Click here for a list of all Faculty Research Lecturers since 1925.

Vault nanoparticles show promise for cancer treatment and possible HIV cure

Dr. Leonard Rome and colleagues publish "Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery" in ACSNano.

The paper is the cover story of the August 26th print edition of the ACSNano journal. Their findings could lead to cancer treatments that are more effective with smaller doses and to therapies that could potentially eradicate the HIV virus. Click here to read the full article.

UCLA hosts "Stem Day" to Promote Science Careers For High School Girls

Biological Chemistry graduate student Martina DeSalvo works with the AWiSE program at UCLA to promote science careers for high school girls.

Biological Chemistry graduate student Jen Quick-Cleveland publishes paper in Cell Reports

"The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin"

Jen Quick-Cleveland from Dr. Feng Guo's lab publishes "The DGCR8 RNA-Binding Heme Domain Recognizes Primary MicroRNAs by Clamping the Hairpin" in Cell Reports. The article describes recognition of microRNA primary transcripts (pri-miRNAs) by the processing machinery is essential for production and biological functions of canonical microRNAs, for evolution of new microRNA genes, and for RNAi applications based on artificial pri-miRNAs. The Guo lab reports that a previously unsuspected heme-binding domain specifically targets key structural features of a pri-miRNA located at both ends of the hairpin helix. Their study demonstrates how extensive pri-miRNA features may be recognized by processing proteins along with a universal biological cofactor.
(From left to right: Sara Weiz, Grant Shoffner, Dr. Feng Guo, Jena Quick-Cleveland, and Jose Jacob)

Pascal Egea named the Alexander and Renee Kolin Endowed Chair

Dr. Pascal Egea has been named to the Alexander and Renee Kolin Endowed Professorship of Molecular Biology and Biophysics Term Chair for five years. This endowed chair is funded by Alexander and Renee Kolin to junior faculty to support career development of a molecular biologist with appointment in the College of Letter and Sciences or the School of Medicine. Pascal’s research focuses on membrane protein structure, targeting, and assembly.

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Celebration for the Ph.D. recipients in Biological Chemistry Labs

Come celebrate the end of the academic year and Honor the 2013-2014 Ph.D. recipients in Biological Chemistry Labs!

When: Wednesday, June 4, 2014, BC Office Lobby @ 2:30pm


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