Clear and penetrating presentation of the basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; functions of pancreatic juice in digestion; elucidation of glycogenic function of the liver.

Faculty Comment: Edward De Robertis:
This 1865 classic is the best description of how new knowledge is generated in Biology (i.e., the epistemology of medical research).  We construct a mental image of how something might work and then test it by experiment.