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AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography. Acta Crystallogr D Struct Biol. 2024 Apr 01.
Miller JE, Agdanowski MP, Dolinsky JL, Sawaya MR, Cascio D, Rodriguez JA, Yeates TO. PMID: 38451205.
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Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J Biol Chem. 2024 Feb; 300(2):105531.
Lu J, Ge P, Sawaya MR, Hughes MP, Boyer DR, Cao Q, Abskharon R, Cascio D, Tayeb-Fligelman E, Eisenberg DS. PMID: 38072051; PMCID: PMC10844680.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins. Appl Magn Reson. 2024; 55(1-3):251-277.
Chen M, Kálai T, Cascio D, Bridges MD, Whitelegge JP, Elgeti M, Hubbell WL. PMID: 38357006; PMCID: PMC10861403.
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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120.
Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 37801475; PMCID: PMC10576031.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens. J Inorg Biochem. 2023 12; 249:112368.
Mahoney BJ, Goring AK, Wang Y, Dasika P, Zhou A, Grossbard E, Cascio D, Loo JA, Clubb RT. PMID: 37729854.
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Humans
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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold. Proc Natl Acad Sci U S A. 2023 09 12; 120(37):e2305494120.
Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JÉ, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO. PMID: 37669364; PMCID: PMC10500258.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379.
Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. PMID: 37185252; PMCID: PMC10127185.
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HumansCells
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The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2211939120.
Macdonald R, Mahoney BJ, Soule J, Goring AK, Ford J, Loo JA, Cascio D, Clubb RT. PMID: 36693107; PMCID: PMC9945957.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets. J Biol Chem. 2022 10; 298(10):102396.
Bowler JT, Sawaya MR, Boyer DR, Cascio D, Bali M, Eisenberg DS. PMID: 35988647; PMCID: PMC9556795.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2119952119.
Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS. PMID: 35377792; PMCID: PMC9169762.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. Proteins. 2022 07; 90(7):1457-1467.
Mahoney BJ, Takayesu A, Zhou A, Cascio D, Clubb RT. PMID: 35194841; PMCID: PMC9177573.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Insight into the molecular basis of substrate recognition by the wall teichoic acid glycosyltransferase TagA. J Biol Chem. 2022 02; 298(2):101464.
Martinez OE, Mahoney BJ, Goring AK, Yi SW, Tran DP, Cascio D, Phillips ML, Muthana MM, Chen X, Jung ME, Loo JA, Clubb RT. PMID: 34864059; PMCID: PMC8784642.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Prospecting for natural products by genome mining and microcrystal electron diffraction. Nat Chem Biol. 2021 08; 17(8):872-877.
Kim LJ, Ohashi M, Zhang Z, Tan D, Asay M, Cascio D, Rodriguez JA, Tang Y, Nelson HM. PMID: 34312563; PMCID: PMC8447837.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium. Acta Crystallogr D Struct Biol. 2021 Jun 01; 77(Pt 6):809-819.
Vadivel K, Schmidt AE, Cascio D, Padmanabhan K, Krishnaswamy S, Brandstetter H, Bajaj SP. PMID: 34076594; PMCID: PMC8171065.
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PubMed Mentions:
2 Translation:
HumansCells
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Isolation and X-ray Crystal Structure of an Electrogenerated TEMPO-N3 Charge-Transfer Complex. Org Lett. 2021 01 15; 23(2):454-458.
Nelson HM, Siu JC, Saha A, Cascio D, MacMillan SN, Wu SB, Lu C, Rodríguez JA, Houk KN, Lin S. PMID: 33406362.
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5 Fields:
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CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun. 2020 08 14; 11(1):4090.
Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS. PMID: 32796831; PMCID: PMC7427792.
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PubMed Mentions:
38 Fields:
Translation:
Humans
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Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020 07 31; 295(31):10662-10676.
Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. PMID: 32493775; PMCID: PMC7397112.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8.
Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2019 Oct; 26(10):988.
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 31530939; PMCID: PMC7103477.
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Cooperative DNA binding by proteins through DNA shape complementarity. Nucleic Acids Res. 2019 09 19; 47(16):8874-8887.
Hancock SP, Cascio D, Johnson RC. PMID: 31616952; PMCID: PMC7145599.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J Biol Chem. 2019 11 01; 294(44):16451-16464.
Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. PMID: 31537646; PMCID: PMC6827308.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Characterization of Reactive Organometallic Species via MicroED. ACS Cent Sci. 2019 Sep 25; 5(9):1507-1513.
Jones CG, Asay M, Kim LJ, Kleinsasser JF, Saha A, Fulton TJ, Berkley KR, Cascio D, Malyutin AG, Conley MP, Stoltz BM, Lavallo V, Rodríguez JA, Nelson HM. PMID: 31572777; PMCID: PMC6764211.
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PubMed Mentions:
13
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Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun. 2019 07 26; 10(1):3357.
Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. PMID: 31350392; PMCID: PMC6659688.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria. PLoS Pathog. 2019 04; 15(4):e1007723.
Kattke MD, Gosschalk JE, Martinez OE, Kumar G, Gale RT, Cascio D, Sawaya MR, Philips M, Brown ED, Clubb RT. PMID: 31002736; PMCID: PMC6493773.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. IUCrJ. 2019 Mar 01; 6(Pt 2):197-205.
Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA. PMID: 30867917; PMCID: PMC6400192.
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9 Fields:
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Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE. Nat Chem Biol. 2019 02; 15(2):132-140.
Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J. PMID: 30559425; PMCID: PMC6339579.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains. J Biol Chem. 2018 11 23; 293(47):18365-18377.
Macdonald R, Cascio D, Collazo MJ, Phillips M, Clubb RT. PMID: 30301765; PMCID: PMC6254355.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition. Elife. 2018 10 05; 7.
Chen W, Mandali S, Hancock SP, Kumar P, Collazo M, Cascio D, Johnson RC. PMID: 30289389; PMCID: PMC6188088.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2018 06; 25(6):463-471.
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 29786080; PMCID: PMC5990464.
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PubMed Mentions:
98 Fields:
Translation:
HumansCells
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Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism. Acta Crystallogr D Struct Biol. 2018 05 01; 74(Pt 5):411-421.
Thompson MC, Cascio D, Yeates TO. PMID: 29717712; PMCID: PMC5930349.
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PubMed Mentions:
6 Translation:
Cells
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Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat Struct Mol Biol. 2018 04; 25(4):311-319.
Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. PMID: 29531287; PMCID: PMC6056015.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science. 2018 02 09; 359(6376):698-701.
Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. PMID: 29439243; PMCID: PMC6192703.
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PubMed Mentions:
195 Fields:
Translation:
HumansCells
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Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nat Struct Mol Biol. 2018 02; 25(2):131-134.
Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. PMID: 29335561; PMCID: PMC6170007.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902.
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Structure-based inhibitors of tau aggregation. Nat Chem. 2018 02; 10(2):170-176.
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. PMID: 29359764; PMCID: PMC5784779.
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PubMed Mentions:
116 Fields:
Translation:
HumansCells
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Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes for structural studies. Biochem Biophys Res Commun. 2017 06 17; 488(1):129-135.
AhYoung AP, Lu B, Cascio D, Egea PF. PMID: 28479252; PMCID: PMC6061939.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 2017 01 03; 6.
Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. PMID: 28045370; PMCID: PMC5207774.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal. PLoS One. 2016; 11(12):e0167763.
Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT. PMID: 27936128; PMCID: PMC5148588.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response. Acta Crystallogr F Struct Biol Commun. 2016 12 01; 72(Pt 12):863-869.
Bajaj RA, Arbing MA, Shin A, Cascio D, Miallau L. PMID: 27917833; PMCID: PMC5137462.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Characterization of WY 14,643 and its Complex with Aldose Reductase. Sci Rep. 2016 10 10; 6:34394.
Sawaya MR, Verma M, Balendiran V, Rath NP, Cascio D, Balendiran GK. PMID: 27721416; PMCID: PMC5056380.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11232-11236.
Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. PMID: 27647903; PMCID: PMC5056061.
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PubMed Mentions:
59 Fields:
Translation:
Cells
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A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein. J Mol Biol. 2016 10 09; 428(20):4013-4030.
Wheatley NM, Eden KD, Ngo J, Rosinski JS, Sawaya MR, Cascio D, Collazo M, Hoveida H, Hubbell WL, Yeates TO. PMID: 27464895; PMCID: PMC5048545.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis. PLoS One. 2016; 11(3):e0150189.
Hancock SP, Stella S, Cascio D, Johnson RC. PMID: 26959646; PMCID: PMC4784862.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum. Protein Sci. 2016 Mar; 25(3):689-701.
AhYoung AP, Koehl A, Vizcarra CL, Cascio D, Egea PF. PMID: 26701219; PMCID: PMC4815404.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Origins of stereoselectivity in evolved ketoreductases. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7065-72.
Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN. PMID: 26644568; PMCID: PMC4697376.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife. 2015 Nov 18; 4:e10935.
Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS. PMID: 26576950; PMCID: PMC4758944.
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PubMed Mentions:
22 Fields:
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Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science. 2015 Oct 30; 350(6260):aab4070.
Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J. PMID: 26472759; PMCID: PMC4687456.
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PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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Uncovering the Mechanism of Aggregation of Human Transthyretin. J Biol Chem. 2015 Nov 27; 290(48):28932-43.
Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. PMID: 26459562; PMCID: PMC4661406.
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PubMed Mentions:
64 Fields:
Translation:
HumansCells
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Structure of the toxic core of α-synuclein from invisible crystals. Nature. 2015 Sep 24; 525(7570):486-90.
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. PMID: 26352473; PMCID: PMC4791177.
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PubMed Mentions:
271 Fields:
Translation:
HumansCells
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Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. J Am Chem Soc. 2015 Aug 12; 137(31):9885-93.
Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y. PMID: 26172141; PMCID: PMC4922798.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design. Protein Sci. 2015 Sep; 24(9):1508-20.
AhYoung AP, Koehl A, Cascio D, Egea PF. PMID: 26130467; PMCID: PMC4570544.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein. Protein Sci. 2015 Jun; 24(6):956-75.
Thompson MC, Cascio D, Leibly DJ, Yeates TO. PMID: 25752492; PMCID: PMC4456109.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021.
Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. PMID: 25728769; PMCID: PMC4904734.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1. J Mol Biol. 2015 Feb 27; 427(4):807-823.
Singh M, Wang Z, Cascio D, Feigon J. PMID: 25553844; PMCID: PMC4323627.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex. Biochem Biophys Res Commun. 2015 Jan 02; 456(1):403-9.
Peng M, Cascio D, Egea PF. PMID: 25475729; PMCID: PMC5023060.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem. 2014 Oct 03; 289(40):27513-25.
Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. PMID: 25138218; PMCID: PMC4183792.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12769-74.
Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS. PMID: 25136092; PMCID: PMC4156696.
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PubMed Mentions:
51 Fields:
Translation:
Cells
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Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. PLoS One. 2013; 8(11):e81753.
Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D. PMID: 24312350; PMCID: PMC3843698.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. Nucleic Acids Res. 2013 Jul; 41(13):6750-60.
Hancock SP, Ghane T, Cascio D, Rohs R, Di Felice R, Johnson RC. PMID: 23661683; PMCID: PMC3711457.
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PubMed Mentions:
47 Fields:
Translation:
Cells
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Tetramerization reinforces the dimer interface of MnSOD. PLoS One. 2013; 8(5):e62446.
Sheng Y, Durazo A, Schumacher M, Gralla EB, Cascio D, Cabelli DE, Valentine JS. PMID: 23667478; PMCID: PMC3646814.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins. J Magn Reson. 2013 Jul; 232:53-61.
Toledo Warshaviak D, Khramtsov VV, Cascio D, Altenbach C, Hubbell WL. PMID: 23694751; PMCID: PMC3758229.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins. Protein Sci. 2013 May; 22(5):660-5.
Wheatley NM, Gidaniyan SD, Liu Y, Cascio D, Yeates TO. PMID: 23456886; PMCID: PMC3649267.
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PubMed Mentions:
43 Fields:
Translation:
Cells
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Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure. 2013 Apr 02; 21(4):627-37.
Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. PMID: 23523424; PMCID: PMC3791866.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Structural and functional studies of γ-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physiological calcium. J Mol Biol. 2013 Jun 12; 425(11):1961-1981.
Vadivel K, Agah S, Messer AS, Cascio D, Bajaj MS, Krishnaswamy S, Esmon CT, Padmanabhan K, Bajaj SP. PMID: 23454357; PMCID: PMC4017951.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
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The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Sci. 2012 Nov; 21(11):1754-67.
Min AB, Miallau L, Sawaya MR, Habel J, Cascio D, Eisenberg D. PMID: 23011806; PMCID: PMC3527712.
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PubMed Mentions:
36 Fields:
Translation:
Cells
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Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Mol Biol Cell. 2012 Nov; 23(22):4416-29.
Gorynia S, Lorenz TC, Costaguta G, Daboussi L, Cascio D, Payne GS. PMID: 22993212; PMCID: PMC3496615.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14314-9.
Sheng Y, Butler Gralla E, Schumacher M, Cascio D, Cabelli DE, Valentine JS. PMID: 22908245; PMCID: PMC3437902.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Toxicol Appl Pharmacol. 2012 Sep 15; 263(3):303-14.
Tsirulnikov K, Abuladze N, Bragin A, Faull K, Cascio D, Damoiseaux R, Schibler MJ, Pushkin A. PMID: 22819785; PMCID: PMC5575769.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell. 2012 Jul 13; 47(1):16-26.
Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J. PMID: 22705372; PMCID: PMC3398246.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Synthesis, structure, and metalation of two new highly porous zirconium metal-organic frameworks. Inorg Chem. 2012 Jun 18; 51(12):6443-5.
Morris W, Volosskiy B, Demir S, Gándara F, McGrier PL, Furukawa H, Cascio D, Stoddart JF, Yaghi OM. PMID: 22676251.
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PubMed Mentions:
70 Fields:
Translation:
Cells
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Structure of a 16-nm cage designed by using protein oligomers. Science. 2012 Jun 01; 336(6085):1129.
Lai YT, Cascio D, Yeates TO. PMID: 22654051.
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PubMed Mentions:
86 Fields:
Translation:
Cells
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Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 09; 335(6073):1228-31.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. PMID: 22403391; PMCID: PMC3959867.
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PubMed Mentions:
260 Fields:
Translation:
Cells
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Comparison of two yeast MnSODs: mitochondrial Saccharomyces cerevisiae versus cytosolic Candida albicans. J Am Chem Soc. 2011 Dec 28; 133(51):20878-89.
Sheng Y, Stich TA, Barnese K, Gralla EB, Cascio D, Britt RD, Cabelli DE, Valentine JS. PMID: 22077216; PMCID: PMC3268005.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Sci. 2011 Nov; 20(11):1876-90.
Laganowsky A, Zhao M, Soriaga AB, Sawaya MR, Cascio D, Yeates TO. PMID: 21898649; PMCID: PMC3267952.
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PubMed Mentions:
31 Fields:
Translation:
Cells
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Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16938-43.
Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. PMID: 21949245; PMCID: PMC3193189.
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PubMed Mentions:
144 Fields:
Translation:
HumansCells
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Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16241-6.
Fleissner MR, Bridges MD, Brooks EK, Cascio D, Kálai T, Hideg K, Hubbell WL. PMID: 21911399; PMCID: PMC3182725.
View in:
PubMed Mentions:
66 Fields:
Translation:
Cells
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Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation. Protein Sci. 2011 Jun; 20(6):996-1004.
Zhao M, Cascio D, Sawaya MR, Eisenberg D. PMID: 21462277; PMCID: PMC3104229.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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Atomic structures suggest determinants of transmission barriers in mammalian prion disease. Biochemistry. 2011 Apr 05; 50(13):2456-63.
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D. PMID: 21323366; PMCID: PMC3068218.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima. Protein Sci. 2011 Jan; 20(1):168-78.
Forse GJ, Ram N, Banatao DR, Cascio D, Sawaya MR, Klock HE, Lesley SA, Yeates TO. PMID: 21082721; PMCID: PMC3047073.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. Protein Sci. 2010 Sep; 19(9):1692-703.
Arbing MA, Kaufmann M, Phan T, Chan S, Cascio D, Eisenberg D. PMID: 20629176; PMCID: PMC2975133.
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PubMed Mentions:
16 Fields:
Translation:
Cells
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Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease. J Biol Chem. 2010 Sep 24; 285(39):29671-5.
Apostol MI, Sawaya MR, Cascio D, Eisenberg D. PMID: 20685658; PMCID: PMC2943325.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci. 2010 Jul; 19(7):1354-65.
Senturia R, Faller M, Yin S, Loo JA, Cascio D, Sawaya MR, Hwang D, Clubb RT, Guo F. PMID: 20506313; PMCID: PMC2974827.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci. 2010 May; 19(5):1031-43.
Laganowsky A, Benesch JL, Landau M, Ding L, Sawaya MR, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. PMID: 20440841; PMCID: PMC2868245.
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PubMed Mentions:
131 Fields:
Translation:
HumansAnimalsCells
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The shape of the DNA minor groove directs binding by the DNA-bending protein Fis. Genes Dev. 2010 Apr 15; 24(8):814-26.
Stella S, Cascio D, Johnson RC. PMID: 20395367; PMCID: PMC2854395.
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PubMed Mentions:
105 Fields:
Translation:
Cells
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Site-directed spin labeling of a genetically encoded unnatural amino acid. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21637-42.
Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. PMID: 19995976; PMCID: PMC2799802.
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PubMed Mentions:
89 Fields:
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Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol. 2009 Sep; 16(9):973-8.
Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D. PMID: 19684598; PMCID: PMC3640378.
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PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin). 2009 May-Jun; 3(3):167-70.
Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. PMID: 19574737; PMCID: PMC3719987.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Structural origin of weakly ordered nitroxide motion in spin-labeled proteins. Protein Sci. 2009 May; 18(5):893-908.
Fleissner MR, Cascio D, Hubbell WL. PMID: 19384990; PMCID: PMC2771293.
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PubMed Mentions:
58 Fields:
Translation:
Cells
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Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1. J Biol Chem. 2009 Jan 16; 284(3):1906-16.
Singh M, Gonzales FA, Cascio D, Heckmann N, Chanfreau G, Feigon J. PMID: 19019820; PMCID: PMC2615527.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17742-7.
Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J. PMID: 18988731; PMCID: PMC2584669.
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PubMed Mentions:
265 Fields:
Translation:
AnimalsCells
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Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem. 2009 Jan 02; 284(1):276-283.
Miallau L, Faller M, Chiang J, Arbing M, Guo F, Cascio D, Eisenberg D. PMID: 18952600; PMCID: PMC2610494.
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PubMed Mentions:
68 Fields:
Translation:
Cells
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The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008 Aug 08; 321(5890):810-4.
Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. PMID: 18599740; PMCID: PMC3654663.
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PubMed Mentions:
271 Fields:
Translation:
Cells
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Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci. 2008 Sep; 17(9):1467-74.
Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D. PMID: 18556473; PMCID: PMC2525530.
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PubMed Mentions:
139 Fields:
Translation:
HumansCells
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Structures and functional implications of an AMP-binding cystathionine beta-synthase domain protein from a hyperthermophilic archaeon. J Mol Biol. 2008 Jun 27; 380(1):181-92.
King NP, Lee TM, Sawaya MR, Cascio D, Yeates TO. PMID: 18513746; PMCID: PMC2577872.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin). 2007 Nov-Dec; 1(6):397-9.
Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. PMID: 18690047.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 2008 Feb; 17(2):228-39.
Guo Z, Cascio D, Hideg K, Hubbell WL. PMID: 18096642; PMCID: PMC2222722.
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PubMed Mentions:
63 Fields:
Translation:
Cells
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The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18467-72.
Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. PMID: 17962412; PMCID: PMC2141800.
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PubMed Mentions:
49 Fields:
Translation:
Cells
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Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 2007 Jun; 16(6):1069-86.
Guo Z, Cascio D, Hideg K, Kálái T, Hubbell WL. PMID: 17473014; PMCID: PMC2206656.
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PubMed Mentions:
64 Fields:
Translation:
Cells
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Discovery of a thermophilic protein complex stabilized by topologically interlinked chains. J Mol Biol. 2007 May 18; 368(5):1332-44.
Boutz DR, Cascio D, Whitelegge J, Perry LJ, Yeates TO. PMID: 17395198; PMCID: PMC1955483.
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PubMed Mentions:
34 Fields:
Translation:
Cells
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Structure of the cooperative Xis-DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2109-14.
Abbani MA, Papagiannis CV, Sam MD, Cascio D, Johnson RC, Clubb RT. PMID: 17287355; PMCID: PMC1893000.
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PubMed Mentions:
36 Fields:
Translation:
Cells
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Fis targets assembly of the Xis nucleoprotein filament to promote excisive recombination by phage lambda. J Mol Biol. 2007 Mar 23; 367(2):328-43.
Papagiannis CV, Sam MD, Abbani MA, Yoo D, Cascio D, Clubb RT, Johnson RC. PMID: 17275024; PMCID: PMC1852488.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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An approach to crystallizing proteins by synthetic symmetrization. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16230-5.
Banatao DR, Cascio D, Crowley CS, Fleissner MR, Tienson HL, Yeates TO. PMID: 17050682; PMCID: PMC1637565.
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PubMed Mentions:
41 Fields:
Translation:
Cells
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Crystallization, dehydration and preliminary X-ray analysis of excisionase (Xis) proteins cooperatively bound to DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 01; 62(Pt 8):825-8.
Sam MD, Abbani MA, Cascio D, Johnson RC, Clubb RT. PMID: 16880568; PMCID: PMC2242933.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. J Biol Chem. 2006 Aug 04; 281(31):21577-21581.
Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J. PMID: 16774926.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8060-5.
Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D. PMID: 16690741; PMCID: PMC1472429.
View in:
PubMed Mentions:
447 Fields:
Translation:
Cells
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Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer. J Biol Chem. 2005 Jul 29; 280(30):27769-75.
Kim CA, Sawaya MR, Cascio D, Kim W, Bowie JU. PMID: 15905166.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus. Structure. 2005 Apr; 13(4):637-48.
Johnson E, Cascio D, Sawaya MR, Gingery M, Schröder I. PMID: 15837202.
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PubMed Mentions:
42 Fields:
Translation:
Cells
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Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J Mol Biol. 2004 Aug 06; 341(2):503-17.
Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CM, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, Sawaya MR. PMID: 15276840.
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PubMed Mentions:
29 Fields:
Translation:
Cells
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A web-based comparative genomics tutorial for investigating microbial genomes. Microbiol Educ. 2004 May; 5:30-5.
Strong M, Cascio D, Eisenberg D. PMID: 23653555; PMCID: PMC3633132.
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PubMed Mentions:
2
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Crystal structure of the excisionase-DNA complex from bacteriophage lambda. J Mol Biol. 2004 Apr 23; 338(2):229-40.
Sam MD, Cascio D, Johnson RC, Clubb RT. PMID: 15066428.
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PubMed Mentions:
30 Fields:
Translation:
Cells
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Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophys Chem. 2003 Sep; 105(2-3):361-70.
Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D. PMID: 14499904.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Structural and EPR characterization of the soluble form of cytochrome c-550 and of the psbV2 gene product from the cyanobacterium Thermosynechococcus elongatus. Plant Cell Physiol. 2003 Jul; 44(7):697-706.
Kerfeld CA, Sawaya MR, Bottin H, Tran KT, Sugiura M, Cascio D, Desbois A, Yeates TO, Kirilovsky D, Boussac A. PMID: 12881497.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells
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Crystallization and preliminary X-ray crystallographic analysis of the excisionase-DNA complex from bacteriophage lambda. Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1238-40.
Sam MD, Cascio D, Johnson R, Clubb RT. PMID: 12832771.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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The 1.6 A resolution structure of Fe-superoxide dismutase from the thermophilic cyanobacterium Thermosynechococcus elongatus. J Biol Inorg Chem. 2003 Sep; 8(7):707-14.
Kerfeld CA, Yoshida S, Tran KT, Yeates TO, Cascio D, Bottin H, Berthomieu C, Sugiura M, Boussac A. PMID: 12827458.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10; 325(2):355-65.
Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. PMID: 12488100.
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PubMed Mentions:
56 Fields:
Translation:
HumansCells
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The crystal structure of a cyanobacterial water-soluble carotenoid binding protein. Structure. 2003 Jan; 11(1):55-65.
Kerfeld CA, Sawaya MR, Brahmandam V, Cascio D, Ho KK, Trevithick-Sutton CC, Krogmann DW, Yeates TO. PMID: 12517340.
View in:
PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
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Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets. Acta Crystallogr D Biol Crystallogr. 2002 Apr; 58(Pt 4):571-8.
Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D. PMID: 11914479.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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An ancestral nuclear protein assembly: crystal structure of the Methanopyrus kandleri histone. Protein Sci. 2001 Oct; 10(10):2002-7.
Fahrner RL, Cascio D, Lake JA, Slesarev A. PMID: 11567091; PMCID: PMC2374223.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5532-7.
Mura C, Cascio D, Sawaya MR, Eisenberg DS. PMID: 11331747; PMCID: PMC33247.
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PubMed Mentions:
45 Fields:
Translation:
Cells
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Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. Biochemistry. 2000 Jul 25; 39(29):8396-405.
Langen R, Oh KJ, Cascio D, Hubbell WL. PMID: 10913245.
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PubMed Mentions:
120 Fields:
Translation:
Cells
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Monomeric structure of the human EphB2 sterile alpha motif domain. J Biol Chem. 1999 Dec 24; 274(52):37301-6.
Thanos CD, Faham S, Goodwill KE, Cascio D, Phillips M, Bowie JU. PMID: 10601296.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Sci. 1999 Jul; 8(7):1410-22.
Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. PMID: 10422829; PMCID: PMC2144380.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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The 1.8 A crystal structure of the ycaC gene product from Escherichia coli reveals an octameric hydrolase of unknown specificity. Structure. 1998 Oct 15; 6(10):1329-37.
Colovos C, Cascio D, Yeates TO. PMID: 9782055.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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NarL dimerization? Suggestive evidence from a new crystal form. Biochemistry. 1998 Mar 17; 37(11):3665-76.
Baikalov I, Schröder I, Kaczor-Grzeskowiak M, Cascio D, Gunsalus RP, Dickerson RE. PMID: 9521685.
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PubMed Mentions:
25 Fields:
Translation:
Cells
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Structure of a DNA analog of the primer for HIV-1 RT second strand synthesis. J Mol Biol. 1997 Jun 27; 269(5):811-26.
Han GW, Kopka ML, Cascio D, Grzeskowiak K, Dickerson RE. PMID: 9223643.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. Biochemistry. 1994 Nov 22; 33(46):13593-610.
Kopka ML, Goodsell DS, Baikalov I, Grzeskowiak K, Cascio D, Dickerson RE. PMID: 7947769.
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PubMed Mentions:
22 Fields:
Translation:
Cells
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Crystallization studies of the human immunodeficiency virus (HIV-1) Tat protein and its trans-activation response element (TAR) RNA. Acta Crystallogr D Biol Crystallogr. 1994 Jul 01; 50(Pt 4):527-34.
McKenna MC, Anderson D, Cascio D, Eisenberg D. PMID: 15299414.
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PubMed Mentions: Fields:
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Crystal structure of the unactivated ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with a transition state analog, 2-carboxy-D-arabinitol 1,5-bisphosphate. Protein Sci. 1994 Jan; 3(1):64-9.
Zhang KY, Cascio D, Eisenberg D. PMID: 8142899; PMCID: PMC2142487.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF). J Mol Biol. 1993 Dec 05; 234(3):640-53.
Lovejoy B, Cascio D, Eisenberg D. PMID: 7504736.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Formation of the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase by a disorder-order transition from the unactivated to the activated form. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9968-72.
Schreuder HA, Knight S, Curmi PM, Andersson I, Cascio D, Brändén CI, Eisenberg D. PMID: 8234342; PMCID: PMC47694.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii. Biochemistry. 1993 Oct 12; 32(40):10560-7.
Redinbo MR, Cascio D, Choukair MK, Rice D, Merchant S, Yeates TO. PMID: 8399201.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Crystallographic analysis of C-C-A-A-G-C-T-T-G-G and its implications for bending in B-DNA. Biochemistry. 1993 Aug 31; 32(34):8923-31.
Grzeskowiak K, Goodsell DS, Kaczor-Grzeskowiak M, Cascio D, Dickerson RE. PMID: 8364037.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Crystal structure of activated tobacco rubisco complexed with the reaction-intermediate analogue 2-carboxy-arabinitol 1,5-bisphosphate. Protein Sci. 1993 Jul; 2(7):1136-46.
Schreuder HA, Knight S, Curmi PM, Andersson I, Cascio D, Sweet RM, Brändén CI, Eisenberg D. PMID: 8358296; PMCID: PMC2142417.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Crystal structure of CATGGCCATG and its implications for A-tract bending models. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2930-4.
Goodsell DS, Kopka ML, Cascio D, Dickerson RE. PMID: 8464909; PMCID: PMC46210.
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PubMed Mentions:
42 Fields:
Translation:
Cells
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Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science. 1993 Feb 26; 259(5099):1288-93.
Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D. PMID: 8446897.
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PubMed Mentions:
69 Fields:
Translation:
Cells
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Crystal structure of the unactivated form of ribulose-1,5-bisphosphate carboxylase/oxygenase from tobacco refined at 2.0-A resolution. J Biol Chem. 1992 Aug 25; 267(24):16980-9.
Curmi PM, Cascio D, Sweet RM, Eisenberg D, Schreuder H. PMID: 1512238.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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X-ray grade crystals of a designed alpha-helical coiled coil. Protein Sci. 1992 Jul; 1(7):956-7.
Lovejoy B, Le TC, Lüthy R, Cascio D, O'Neil KT, DeGrado WF, Eisenberg D. PMID: 1304378; PMCID: PMC2142157.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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The structure of DAPI bound to DNA. J Biomol Struct Dyn. 1989 Dec; 7(3):477-91.
Larsen TA, Goodsell DS, Cascio D, Grzeskowiak K, Dickerson RE. PMID: 2627296.
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PubMed Mentions:
49 Fields:
Translation:
Cells
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Refined atomic model of glutamine synthetase at 3.5 A resolution. J Biol Chem. 1989 Oct 25; 264(30):17681-90.
Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D. PMID: 2572586.
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PubMed Mentions:
44 Fields:
Translation:
Cells
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Tertiary structure of plant RuBisCO: domains and their contacts. Science. 1988 Jul 01; 241(4861):71-4.
Chapman MS, Suh SW, Curmi PM, Cascio D, Smith WW, Eisenberg DS. PMID: 3133767.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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A crystal form of ribulose-1,5-bisphosphate carboxylase/oxygenase from Nicotiana tabacum in the activated state. J Mol Biol. 1987 Sep 20; 197(2):363-5.
Suh SW, Cascio D, Chapman MS, Eisenberg D. PMID: 3681999.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO. Cold Spring Harb Symp Quant Biol. 1987; 52:483-90.
Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW. PMID: 2900091.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells