
Tamir Gonen
351C BSRB
615 Charles Young Dr.
David Geffen School of Medicine at UCLA
Department of Biological Chemistry
Los Angeles, CA 90095
Research
Position Titles
2002 – 2005 Postdoctoral fellow, Harvard Medical School
2005 – 2010 Assistant Professor, University of Washington School of Medicine
2009 – 2011 Early Career Scientist, Howard Hughes Medical Institute
2010 – 2011 Associate Professor with Tenure, University of Washington School of Medicine
2011 – 2017 Group Leader, Janelia Research Campus, Howard Hughes Medical Institute
2017 – Current, Professor, Biological Chemistry and Physiology, David Geffen School Of Medicine, University of California, Los Angeles
2017 – Current Investigator, Howard hughes Medical Institute
Biography
Dr Gonen is an expert in electron crystallography and cryo EM. He determined the 1.9Å resolution structure of the water channel aquaporin-0 by electron crystallography, the highest resolution for any protein determined by cryo EM techniques at the time. Dr Gonen established his own laboratory at the University of Washington in 2005 together with the very first cryo EM laboratory in the Pacific Northwest, a resource that continues to benefit many researchers at the UW School of Medicine and beyond. He has authored many publications from his laboratory concerning membrane protein structure and function. Dr Gonen was honored with a Career Development award from the American Diabetes Association as well as being chosen one of only 50 Howard Hughes Medical Institute Early Career Scientists around the country. In 2011 Dr Gonen accepted a position as a Group Leader at the HHMI Janelia Research Campus where he began developing MicroED as a new method for structural biology. With this method Dr Gonen has pushed the boundaries of cryoEM and determined a number of previously unknown structures at resolutions close to 1Å. In 2012 he became a Member of the Royal Society of New Zealand and in a Professor of Biological Chemistry and Physiology at the David Geffen School of Medicine of the University of California, Los Angeles and an Investigator of the Howard Hughes Medical Institute.
Research Description
Our laboratory studies the structures of membrane proteins important in homeostasis and signaling. We develop new tools in structural biology, namely MicroED as a new method for cryo EM, to facilitate the study of such membrane proteins to atomic resolution from vanishingly small crystals.
Awards & Honors
1996 Deans List – Organic Chemistry, University of Auckland, New Zealand
1996 Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1997 Center for Gene Technology Research Scholarship, University of Auckland, New Zealand
1997 Deans List – Inorganic Chemistry, University of Auckland, New Zealand
1998 Senior Prize in Biological Sciences, University of Auckland, New Zealand
1998 First Class Honors in Biological Sciences, University of Auckland, New Zealand
1999 University of Auckland Doctoral Scholarship, University of Auckland, New Zealand
2000 Contestable Travel Fund Award, University of Auckland, New Zealand
2001 Contestable Travel Fund Award, University of Auckland, New Zealand
2009 American Diabetes Association Career Development Award
2009 Howard Hughes Medical Institute Early Career Scientist
2010 New Investigator Science in Medicine Lecture
2012 Member, The Royal Society of New Zealand
2017 Investigator, Howard Hughes Medical Institute